Cell-Free DNA, A Diagnostic Marker For Cancer

Cell-Free DNA, A Diagnostic Marker For Cancer


Cell free DNA (cfDNA) is a screening test for the blood of a woman which can be conducted, and it’s optional, between nine to ten weeks of pregnancy. The screening is of importance as it shows the availability of certain genetic conditions in the pregnancy and determines whether the chances of these conditions put the human at high risk of complications or lower. 

In addition, the screening test can also predict whether the unborn baby in the womb is a girl or boy. The results relayed from this test are neither yes/no nor positive, it is a requirement that the results should be confirmed by directing it to a diagnostic test for example, through amniocentesis if a conclusive info is anticipated for.

How cfDNA is used for cancer

It has been discovered that Cell free DNA has greatly shown a positive impact on the detection, diagnose and in the treatment of many cancer-related diseases. For a long period of challenges as to the treatment of cancer has ever arisen as the disease mimics different biomolecule and signals reduce the immune system strength.

The biggest challenge in the cancer treatment has ever been the detection. The blood apoptosis is the region where the amount of cfDNA if found, however, the amount which is to be determined is greatly influenced by necrosis and since apoptosis is the main release of cfDNA, the detection shall show some short fragments generated within the blood.

An assessment of transmission the cfDNA delivers info regarding intergrowth heterogeneity motives for main opposition, detection of minimal remaining disease and the disease evolution. In precise, the assessment of the ctDNA could permit for the restoration of the reorganizations and the epigenetic status of the growth genome and the identification of the possibly metastatic clonal and sub clonal cells.

The noninvasive example group and the easy to perform the movement of cfDNA examination may sometimes make a decent diagnosis instrument. ctDNA examination substitutes the tissue operations and this can with no trouble be repetitive severally, permitting the growth encumbrance and the management response nursing and timely proof of identity of deterioration.

The prenatal testing

The prenatal cfDNA screening using a cfDNA extraction kit inclines to be the greatest perfect screening examination for Down syndrome which is far much better than the old-fashioned screening exams like the quad screen and the first-trimester screening. It is not an affirmative or not at all screening but an assessment where false positive and false negative transpire.

The typical prenatal cfDNA screening consequences diminish the chance of the disorder screened but it does not rule them out. It does not assess for all chromosome complaints or birth imperfections but may disclose other conditions in the expectant mother or in the developing baby. If an individual’s prenatal cfDNA screening results come positive, amniocentesis is commended to give you responses if you desire.

Other screening testing

Other screening testing includes the traditional tests such as the quad screen and the first-trimester screening. The quad screening is one which is carried out in the second trimester usually between fifteen to twenty weeks of pregnancy while first-trimester screening is that which is done between week eleven and fourteen of pregnancy. All shows the risk of carrying a baby with Down syndrome.


cfDNA is the latest scientifically proved method and is the most important in the screening of cancer. It provides for early cancer detection mostly on pregnant women. Early detection and treatment of cancer-related diseases lead to better health as the disease shall have been prevented at earlier stages.

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